Abiraterone Acetate Withdrawal Syndrome: Does It Exist?
نویسندگان
چکیده
In 2011 abiraterone acetate (AA) was approved for the treatment of castrate-resistant metastatic prostate cancer patients who have failed docetaxel chemotherapy. We report the case of a patient who experienced a confirmed PSA decrease of ≤50% after stopping AA, mimicking an antiandrogen withdrawal syndrome.
منابع مشابه
Biochemical and objective response to abiraterone acetate withdrawal: incidence and clinical relevance of a new scenario for castration-resistant prostate cancer.
OBJECTIVE To describe the incidence and clinical relevance of biochemical and objective responses to abiraterone acetate (AA) withdrawal (AAWD) in patients with castration-resistant prostate cancer (CRPC). MATERIALS AND METHODS Twenty-six patients with progressive CRPC treated with first-line docetaxel-based chemotherapy were administered with AA at the standard dose of 1000 mg/day in combina...
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BACKGROUND The value of continuation of luteinizing hormone-releasing hormone (LHRH) therapy in castration-resistant prostate cancer (CRPC) remains controversial and clear evidence is lacking. Argumentation for cessation of LHRH therapy is the prolonged suppression of testosterone levels after the withdrawal of LHRH analogues and the fact that disease progression occurs despite castration level...
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Abiraterone acetate is the first second-line hormonal agent proven to improve survival in metastatic castration-resistant prostate cancer. It selectively inhibits cytochrome P450 17 (CYP17) α-hydroxylase and cytochrome17,20 (C17,20)-lyase, which are enzymes critical for androgen synthesis. Abiraterone acetate was initially approved in the United States in 2011 after demonstrating a 4-month surv...
متن کاملA phase 3, double-blind, randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapy-naïve patients with mCRPC in China, Malaysia, Thailand and Russia
Objective This double-blind, placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate + prednisone (abiraterone) to prednisone alone in chemotherapy-naïve, asymptomatic or mildly symptomatic metastatic castration-resistant prostate cancer (mCRPC) patients from China, Malaysia, Thailand and Russia. Methods Adult chemotherapy-naïve patients with confir...
متن کاملLATITUDE: A Phase III, Double-Blind, Randomized Trial of Androgen Deprivation Therapy with Abiraterone Acetate Plus Predni- sone or Placebos in Newly Diagnosed High-Risk Metastatic Hormone-Naive Prostate Cancer
Dr. Fizazi and colleagues presented their much anticipated results from the LATITUDE trial at the 2017 American Society of Clinical Oncology (ASCO) annual meeting. LATITUDE is a phase III, double-blind, randomized study that tested androgen deprivation therapy (ADT) with abiraterone acetate (AA) plus prednisone (P) vs. ADT + placebo in men newly diagnosed with highrisk metastatic hormone-naïve ...
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